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irf4  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc irf4
    Macrophage remodeling via MTX@PNSH therapy elicits the reestablishment of immune homeostasis at the transcriptional level. (A) qRT-PCR analysis of relative mRNA of Irf3 with different treatments. (B) qRT-PCR analysis of relative mRNA of <t>Irf4</t> with different treatments. (C) qRT-PCR analysis of relative mRNA of Irf5 with different treatments. (D) qRT-PCR analysis of relative mRNA of Irf8 with different treatments. (E) Heatmap analysis was performed to compare the gene expression of Irf3 , Irf4 , Irf5 , and Irf8 across different treatment groups. (F) Western blotting analysis of IRF4, and IRF8 levels in macrophages after 24 h of different treatment. (G) Quantitative analysis of IRF4 protein expression. (H) Quantitative analysis of IRF8 protein expression. Data are presented as mean ± SD, n = 3. Statistical significance was determined using one-way ANOVA, followed by Dunnett's post hoc test for comparisons between groups.
    Irf4, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/irf4/product/Cell Signaling Technology Inc
    Average 94 stars, based on 26 article reviews
    irf4 - by Bioz Stars, 2026-06
    94/100 stars

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    1) Product Images from "Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodeling"

    Article Title: Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodeling

    Journal: Bioactive Materials

    doi: 10.1016/j.bioactmat.2025.11.031

    Macrophage remodeling via MTX@PNSH therapy elicits the reestablishment of immune homeostasis at the transcriptional level. (A) qRT-PCR analysis of relative mRNA of Irf3 with different treatments. (B) qRT-PCR analysis of relative mRNA of Irf4 with different treatments. (C) qRT-PCR analysis of relative mRNA of Irf5 with different treatments. (D) qRT-PCR analysis of relative mRNA of Irf8 with different treatments. (E) Heatmap analysis was performed to compare the gene expression of Irf3 , Irf4 , Irf5 , and Irf8 across different treatment groups. (F) Western blotting analysis of IRF4, and IRF8 levels in macrophages after 24 h of different treatment. (G) Quantitative analysis of IRF4 protein expression. (H) Quantitative analysis of IRF8 protein expression. Data are presented as mean ± SD, n = 3. Statistical significance was determined using one-way ANOVA, followed by Dunnett's post hoc test for comparisons between groups.
    Figure Legend Snippet: Macrophage remodeling via MTX@PNSH therapy elicits the reestablishment of immune homeostasis at the transcriptional level. (A) qRT-PCR analysis of relative mRNA of Irf3 with different treatments. (B) qRT-PCR analysis of relative mRNA of Irf4 with different treatments. (C) qRT-PCR analysis of relative mRNA of Irf5 with different treatments. (D) qRT-PCR analysis of relative mRNA of Irf8 with different treatments. (E) Heatmap analysis was performed to compare the gene expression of Irf3 , Irf4 , Irf5 , and Irf8 across different treatment groups. (F) Western blotting analysis of IRF4, and IRF8 levels in macrophages after 24 h of different treatment. (G) Quantitative analysis of IRF4 protein expression. (H) Quantitative analysis of IRF8 protein expression. Data are presented as mean ± SD, n = 3. Statistical significance was determined using one-way ANOVA, followed by Dunnett's post hoc test for comparisons between groups.

    Techniques Used: Quantitative RT-PCR, Gene Expression, Western Blot, Expressing



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    Macrophage remodeling via MTX@PNSH therapy elicits the reestablishment of immune homeostasis at the transcriptional level. (A) qRT-PCR analysis of relative mRNA of Irf3 with different treatments. (B) qRT-PCR analysis of relative mRNA of <t>Irf4</t> with different treatments. (C) qRT-PCR analysis of relative mRNA of Irf5 with different treatments. (D) qRT-PCR analysis of relative mRNA of Irf8 with different treatments. (E) Heatmap analysis was performed to compare the gene expression of Irf3 , Irf4 , Irf5 , and Irf8 across different treatment groups. (F) Western blotting analysis of IRF4, and IRF8 levels in macrophages after 24 h of different treatment. (G) Quantitative analysis of IRF4 protein expression. (H) Quantitative analysis of IRF8 protein expression. Data are presented as mean ± SD, n = 3. Statistical significance was determined using one-way ANOVA, followed by Dunnett's post hoc test for comparisons between groups.
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    Image Search Results


    Macrophage remodeling via MTX@PNSH therapy elicits the reestablishment of immune homeostasis at the transcriptional level. (A) qRT-PCR analysis of relative mRNA of Irf3 with different treatments. (B) qRT-PCR analysis of relative mRNA of Irf4 with different treatments. (C) qRT-PCR analysis of relative mRNA of Irf5 with different treatments. (D) qRT-PCR analysis of relative mRNA of Irf8 with different treatments. (E) Heatmap analysis was performed to compare the gene expression of Irf3 , Irf4 , Irf5 , and Irf8 across different treatment groups. (F) Western blotting analysis of IRF4, and IRF8 levels in macrophages after 24 h of different treatment. (G) Quantitative analysis of IRF4 protein expression. (H) Quantitative analysis of IRF8 protein expression. Data are presented as mean ± SD, n = 3. Statistical significance was determined using one-way ANOVA, followed by Dunnett's post hoc test for comparisons between groups.

    Journal: Bioactive Materials

    Article Title: Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodeling

    doi: 10.1016/j.bioactmat.2025.11.031

    Figure Lengend Snippet: Macrophage remodeling via MTX@PNSH therapy elicits the reestablishment of immune homeostasis at the transcriptional level. (A) qRT-PCR analysis of relative mRNA of Irf3 with different treatments. (B) qRT-PCR analysis of relative mRNA of Irf4 with different treatments. (C) qRT-PCR analysis of relative mRNA of Irf5 with different treatments. (D) qRT-PCR analysis of relative mRNA of Irf8 with different treatments. (E) Heatmap analysis was performed to compare the gene expression of Irf3 , Irf4 , Irf5 , and Irf8 across different treatment groups. (F) Western blotting analysis of IRF4, and IRF8 levels in macrophages after 24 h of different treatment. (G) Quantitative analysis of IRF4 protein expression. (H) Quantitative analysis of IRF8 protein expression. Data are presented as mean ± SD, n = 3. Statistical significance was determined using one-way ANOVA, followed by Dunnett's post hoc test for comparisons between groups.

    Article Snippet: Subsequently, 10 mg of protein was loaded into 10 % SDS-polyacrylamide gel electrophoresis for detection of adenosine A2AR (sc-32261, Santa Cruz), IRF4 (#62834S, Cell Signaling Technology, MA, USA), IRF8 (#5628T, Cell Signaling Technology, MA, USA) and GAPDH (TA-08, ZSGB-BIO, Beijing, China).

    Techniques: Quantitative RT-PCR, Gene Expression, Western Blot, Expressing